University of Georgia
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UMA SINGH

Singh, Uma

Assistant Research Scientist, Lecturer
Pharmaceutical and Biomedical Sciences

  • We are an organic medicinal chemistry group and intend in the drug design, discovery, and development. Our research goal is focused on the development of the new antiviral agents for the pre-clinical and clinical drug candidates. We are developing the new nucleoside and nucleotide analogs, targeting the viral polymerases enzymes against the SARS-CoV-1 & 2 (Severe acute respiratory syndrome), MERS-CoV (Middle East respiratory syndrome), hepatitis C virus (HCV), hepatitis B virus (HBV), varicella-zoster virus (VZV), and influenza viruses. In this effort, FMCAP (2′-Fluoro-6′-methylenecarbocyclic Adenosine Phosphoramidate) is developed as a pre-clinical candidate against drug-resistant hepatitis B virus. Another pre-clinical candidate L-BHDU (2-bromovinyl-2-(hydroxymethyl)-1,3 dioxolan uracil) has been developed for the treatment of Shingles. The outbreak of coronaviruses (CoVs) like SARS-CoV-1 & 2 and MERS-CoV is a severe threat to human health and wealth. Whenever viruses threatened human health, our group has been at the forefront of the discovery of antiviral agents. Against COVID-19 life-threatening situations, our group is involved in the design, synthesis, and development of the novel nucleoside/nucleotide analogs and its prodrugs, targeting the RNA dependent RNA polymerase (RdRp), which is an essential enzyme for viral replication. Hence, RdRp is a unique target for antiviral agents, especially for the nucleoside/nucleotide, which mimics the activity of this enzyme and impede viral replication and transmission.