
Maor Bar-Peled
Associate Professor
Plant Biology
Molecular cell biology of the wall, Biofuel and BioEnergy, Golgi as model for System biology, Plant Immunity.
Learn more about this group by contacting Dr. Jacek Gaertig (jgaertig@uga.edu).
Research within this group is focused on the fundamental functions of the cell, such as organelle biogenesis and function, cell polarization, cytoskeleton, cell motility, sensing, signal transduction, intracellular transport, cell cycle regulation and gene expression. Our faculty use interdisciplinary approaches including genetic, biochemical, bioinformatic, biophysical, microscopic imaging and mathematical modeling tools to understand the basic properties of both prokaryotic and eukaryotic cells.
Molecular cell biology of the wall, Biofuel and BioEnergy, Golgi as model for System biology, Plant Immunity.
We use the advanced genetic mouse models to study the molecular and cellular mechanisms underlying
several diseases: obesity, diabetics, muscle and heart diseases.
Meiotic chromosome biology using Drosophila as a model system.
Nuclear and genome organization; Chromatin structure and function; Gene regulation in Drosophila development.
Post-translational modification including protein acylation, fatty acid metabolism,
prostate stem cell, Src family kinases, prostate cancer, small molecular inhibitor.
Plant centromere and kinetochore structure and function.
Cellular and molecular biology of acidocalcisomes; the role of polyphosphate in trypanosomatids.
Genetic analysis of mouse development; cell fate specification in the embryonic
central nervous system; patterning of the body plan’s left-right axis.
Bacterial adhesion and biofilm formation, dynamics of bacterial nanomachines, microbial subcellular organization.
Toxoplasma’s Strategies to Manipulate Host Immunity
Protist systematics, cell evolution, and flagellar development.
Molecular cell biology of the cytoskeleton; molecular genetics of ciliates.
Retrovirus-like transposons in budding yeast, control of transposition, restriction factors.
Defining the spatiotemporal regulation of kinase pathways and the regulation of GPCR induced
inflammation and proangiogenic signaling, for the development of therapeutic agents.
Role of glycosylation in regulating Notch signaling, assisting protein folding, and development.
Translational research in biomaterials (antifouling, antiplatelet, antibacterial, and antiviral) for tissue engineering and medical device applications
Nutrient Regulation of Signaling and Transcription: Mechanisms Underlying Diabetes, Neurodegeneration and Cancer
Gene regulation in bacteria; regulation of flagellar biogenesis; control of RpoN-dependent transcription in bacteria.
The Huet Lab will use metabolomics and CRISPR-based approaches to understand the mitochondrial and organellar biology of a class of protozoan parasites, the apicomplexans.
Transcriptional and epigenetic mechanisms regulating preimplantation development, pluripotency, differentiation and cellular reprogramming in humans
Our research is aimed at identifying the principles of neural circuit assembly, which is key
to understanding the treatment of neurological disorders. To achieve this, we develop
imaging toolkits including fluorescent probes and advanced microscopes.
Website
Chemical biology, kinase signaling, cancer, signal transduction, drug discovery.
Regulation of the cell cycle; ubiquitin-mediated proteolysis and development.
The discovery and development of new drugs to prevent or treat malaria and diseases
caused by brain-eating amoebae. Elucidating mechanism(s) of resistance
and discovering new drug treatment regimens, combinations, or strategies to overcome resistance.
Cell Biology of Cilia; Cilia-related diseases, Intracellular Transport.
Human fungal pathogens, sexual reproduction and development in fungal pathogenesis
Fertilization, and early cell-fate decisions in plant embryos.
Understanding intracellular and intercellular heme transport.
Cellular and molecular biology of polar growth in fungi.
Biochemistry, molecular, and structural biology of mammalian glycoprotein biosynthesis and catabolism.
Metabolism and drug development against protozoan parasites.
Calcium signaling and storage in Toxoplasma gondii.
Molecular and cellular biology of the human malaria parasite, Plasmodium falciparum.
Cell differentiation during plant reproduction, genomics and gene regulatory networks, single-cell RNA-sequencing, reprogramming cell fate
Regeneration and development; understanding cellular/molecular mechanisms that underlie neural regeneration in planarians.
Molecular and biochemical parasitology: DNA modification, homologous recombination
and the regulation of antigenic variation in Trypanosoma brucei.
Molecular cell biology and biochemistry of proteases associated with isoprenylated protein
maturation and amyloidogenic peptide degradation; cancer; Alzheimer’s disease.
Bacterial modulation of eukaryotic membrane dynamics for intracellular survival;
SNARE-dependent membrane fusion biochemistry.
We are developing stem cell approaches to repairing bone and nerve injury in addition to
use of stem cells as a tool to screen toxins and potential drug therapies.
We study CRISPR-Cas immune systems that protect prokaryotes from viruses and provide
powerful research tools for important biotechnology and biomedical applications.
Mammalian germ cell and early embryonic development; meiotic chromosome segregation in oocytes;
genomic instability; impact of age and environment on meiotic division.
Investigating the regulatory mechanisms of glycosylation using genomic, chemical, and genetic approaches with particular focus on the discovery of novel drugs and targets to treat human diseases.
X-ray crystallographic and biochemical studies of nucleotide sugar metabolism.
Develop regenerative therapies for neurological diseases by investigating the pathological and therapeutic roles of extracellular vesicles in cellular and animal models.
Stem cell biology, brown fat development and induction, non-coding
RNA, development of novel therapies for human obesity and type 2 diabetes
Effects of pathological stress on cells of the peripheral nervous system and the adrenal gland. In vitro disease modeling using human pluripotent stem cells.