
Oshri Avraham
Assistant Professor
Cellular Biology
Deciphering the mechanisms that regulate the diversity of peripheral glial cells to achieve a better understanding of their role in the context of disease and injury.
Learn more about this group by contacting Dr. Hongxiang Liu (RBC Grad Program Inquiry Form) or visiting the Regenerative Bioscience Center website.
Regenerative medicine translates biology, chemistry and physics into materials, devices, systems and a variety of therapeutic strategies which repair, replace or regenerate organs and tissues. This rapidly evolving interdisciplinary field in human and veterinary healthcare is transforming the practice of medicine, medical innovation and the production of medical devices and therapies. The purpose of this IG is to foster research and training in this rapidly developing area of bioengineering, veterinary medicine and human health
Deciphering the mechanisms that regulate the diversity of peripheral glial cells to achieve a better understanding of their role in the context of disease and injury.
We use the advanced genetic mouse models to study the molecular and cellular mechanisms underlying
several diseases: obesity, diabetics, muscle and heart diseases.
Mitochondrial bioenergetics of muscle, brain, and stem cells. Skeletal muscle physiology. Regenerative medicine and rehabilitation following traumatic tissue damage, disease, aging.
Research in the Easley lab focuses on 3 major goals: 1) impacts of environmental exposures on spermatogenesis and future generations, 2) regenerative medicine by developing stem cell treatment options for male factor infertility, and 3) drug discovery for identifying unique compounds which may serve as male contraceptives.
Inhibition of glycation and LDL oxidation by natural products and nutraceuticals.
Translational research in biomaterials (antifouling, antiplatelet, antibacterial, and antiviral) for tissue engineering and medical device applications
Transcriptional and epigenetic mechanisms regulating preimplantation development, pluripotency, differentiation and cellular reprogramming in humans
Developing Translational Glycomaterials for Neural Tissue Repair and Neural Interfacing.
Developmental neurobiology: molecular genetic mechanisms of vertebrate eye and forebrain development.
Sensory organs of taste: development, maintenance, and molecular regulations using genetically modified mouse models.
Our research is focused on functional polymer interfaces. We are
currently developing methodologies and platforms that can be used
to study biological lubrication, patterning of cellular components in
two and 3 dimensions, patterning of glycosaminoglycans to study
nerve regeneration, 3D printing of biodegradable scaffolds, and antimicrobial coatings.
Neuroendocrinology Reproductive Aging, Stress Axis and Metabolic Function,
Neuroendocrine-Immune Interactions, Prenatal Programming and its Neuroendocrine Consequences,
Neuroendocrine Effects of Exposure to Environmentally Relevant Chemicals
Neuroendocrine immune interactions in the context of
Reproduction and Stress; Prenatal Stress and programming
of obesity; Environmental exposures and their impact
on Stress and Reproduction; Biomarker development for
various human diseases.
In vivo optical microscopy for bone and tissue regeneration.
Human antibody-mediated immunity to inform next-generation
vaccine development; focus on immunity to major viral, bacterial,
and fungal human pathogens using multidisciplinary approaches in
immunology, structural biology,and biochemistry to study
antibody-antigen interactions at the molecular level.
Cell differentiation during plant reproduction, genomics and gene regulatory networks, single-cell RNA-sequencing, reprogramming cell fate
Regeneration and development; understanding cellular/molecular mechanisms that underlie neural regeneration in planarians.
Population epigenomics and mechanisms of epigenetic inheritance.
We are developing stem cell approaches to repairing bone and nerve injury in addition to
use of stem cells as a tool to screen toxins and potential drug therapies.
Mammalian germ cell and early embryonic development; meiotic chromosome segregation in oocytes;
genomic instability; impact of age and environment on meiotic division.
Stroke is the second leading cause of death worldwide. We explore the potential of neural stem cells
and other regenerative therapies to recover lost and damaged brain tissue. We utilize a novel
pig ischemic stroke model in conjunction with magnetic resonance imaging, cognitive,
motor function testing and histology.
Identify behavioral, cognitive, and neural mechanisms for dexterity; learning and control principles for skilled movement; rehabilitation after neuromuscular injuries.
Develop regenerative therapies for neurological diseases by investigating the pathological and therapeutic roles of extracellular vesicles in cellular and animal models.
Stem cell biology, brown fat development and induction, non-coding
RNA, development of novel therapies for human obesity and type 2 diabetes
Effects of pathological stress on cells of the peripheral nervous system and the adrenal gland. In vitro disease modeling using human pluripotent stem cells.