
Adam W. Barb
Associate Professor
Biochemistry & Molecular Biology
Our goal is to define the impact of protein post-translational modifications on structure and function in the immune system.
Learn more about this group by contacting Dr. Jarrod Mousa (jarrod.mousa@uga.edu).
Structural Biology is interdisciplinary research areas that routinely integrate advanced computing techniques (dynamics, molecular modeling, simulations) and specialized physical methods (crystallography, nuclear magnetic resonance, spectroscopy) to solve exciting questions in biological systems. The disciplines often work at the molecular level and utilize fundamental principles derived from mathematics, chemistry, and physics.
Our goal is to define the impact of protein post-translational modifications on structure and function in the immune system.
Metabolomics and systems biology of Caenorhabditis elegans using NMR,
mass spec, and computational approaches.
Evolutionary systems biology; protein kinase signaling in plants, pathogens and microbes. Evolution and classification of glycoenzymes.
The mechanisms of metalloproteins involved in radical generation, oxidative stress protection,
as well as heme synthesis, sensing, aquisition and transport.
Understanding intracellular and intercellular heme transport.
Biochemistry, molecular, and structural biology of mammalian glycoprotein biosynthesis and catabolism.
Human antibody-mediated immunity to inform next-generation
vaccine development; focus on immunity to major viral, bacterial,
and fungal human pathogens using multidisciplinary approaches in
immunology, structural biology,and biochemistry to study
antibody-antigen interactions at the molecular level.
Enzymes involved in amino acid, especially tryptophan, metabolism which may be drug
targets for cancer, hypertension and neurodegenerative diseases.
Application of Nuclear Magnetic Resonance Spectroscopy to the characterization of biologically important systems.
Development of high-throughput structural biology tools, biophysical methods,
NMR, and computer-aided drug-design to investigate drug-protein
interactions and human disease.
X-ray structural biology, the mitochondrial inner membrane space transport system,
structure based vaccine and therapeutic design, improved/automated methods for
synchrotron SAD data collection and structure determination.
Protein design and engineering, design of anti-virals and immunogens,
protein chemistry and re-purposing of viral surface proteins,
computational biology
Structure and function of enzymes involved in plant polysaccharide biosynthesis and modification with the long term goal to develop pathway engineering or targeted genomics approaches for enhanced production of bio-materials, -products, and -fuels.
Structural biology of transcription regulation, steroid hormone activation and breast cancer.
Structure-function studies by X-ray diffraction, transcription proteins,
structural genomics, phasing methods.
Oxygen- and glycosylation-dependent regulation of polyubiquitin ligases in Dictyostelium and Toxoplasma gondii;
Glycobiology of protozoa.
X-ray crystallographic and biochemical studies of nucleotide sugar metabolism.
Immunological carbohydrate-protein interactions studied by computational simulation and experimental methods.
Computational drug discovery, simulation model, new computational tools for drug design