Mechanisms of immune activation by carbohydrate antigens; design and development
of knowledge-based vaccines and therapeutics against pathogens and cancers.
Metabolomic approaches applied to drug target selection and validation in human pathogens;
discovery and development of new chemotherapeutic interventions.
Stem cell biology, development of cell therapies for type 1 diabetes and cardiovascular disease. Pluripotent stem cells in early development and induced pluripotent stem cells- cell reprogramming.
Structures and functions of the noncellulosic polysaccharides of plant primary cell walls.
Course-based undergraduate research, student integration into the
scientific community; research mentoring of undergraduate researchers.
Metabolomics and systems biology of Caenorhabditis elegans using NMR,
mass spec, and computational approaches.
Molecular and cellular mechanisms of brain tumors; oncohistone mutations; human ES cell-based tumor modeling; tumor heterogeneity and evolution
Role of glycosylation in regulating Notch signaling, assisting protein folding, and development.
Nutrient Regulation of Signaling and Transcription: Mechanisms Underlying Diabetes, Neurodegeneration and Cancer
Transcriptional and epigenetic mechanisms regulating preimplantation development, pluripotency, differentiation and cellular reprogramming in humans
Evolutionary systems biology; protein kinase signaling in plants, pathogens and microbes. Evolution and classification of glycoenzymes.
The mechanisms of metalloproteins involved in radical generation, oxidative stress protection,
as well as heme synthesis, sensing, aquisition and transport.
My research investigates problem solving among biochemistry undergraduates and the process
college science instructors go through as they innovate their teaching.
Biosynthesis and function of the plant cell wall polysaccharide pectin.
Anti-cancer effects of pectin.
Enzymes involved in amino acid, especially tryptophan, metabolism which may be drug
targets for cancer, hypertension and neurodegenerative diseases.
Glycosyltransferase regulation of tumor cell adhesion and invasion; structure/function of lectins.
Application of Nuclear Magnetic Resonance Spectroscopy to the characterization of biologically important systems.
X-ray structural biology, the mitochondrial inner membrane space transport system,
structure based vaccine and therapeutic design, improved/automated methods for
synchrotron SAD data collection and structure determination.
Molecular and biochemical parasitology: DNA modification, homologous recombination
and the regulation of antigenic variation in Trypanosoma brucei.
Molecular cell biology and biochemistry of proteases associated with isoprenylated protein
maturation and amyloidogenic peptide degradation; cancer; Alzheimer’s disease.
We study CRISPR-Cas immune systems that protect prokaryotes from viruses and provide
powerful research tools for important biotechnology and biomedical applications.
Structure and function of enzymes involved in plant polysaccharide biosynthesis and modification with the long term goal to develop pathway engineering or targeted genomics approaches for enhanced production of bio-materials, -products, and -fuels.
Structure-function studies by X-ray diffraction, transcription proteins,
structural genomics, phasing methods.
Investigating the regulatory mechanisms of glycosylation using genomic, chemical, and genetic approaches with particular focus on the discovery of novel drugs and targets to treat human diseases.
Role of protein glycosylation in intellectual disability, congenital muscular dystrophy, cancer, and viral infection.
Oxygen- and glycosylation-dependent regulation of polyubiquitin ligases in Dictyostelium and Toxoplasma gondii;
Glycobiology of protozoa.
Cancer Computational and Systems Biology, Computational Methods for
Protein Structure Prediction and Modeling.
Stem cell biology, brown fat development and induction, non-coding
RNA, development of novel therapies for human obesity and type 2 diabetes
Effects of pathological stress on cells of the peripheral nervous system and the adrenal gland. In vitro disease modeling using human pluripotent stem cells.