
Michael Adams
Distinguished Research Professor
Biochemistry & Molecular Biology
Functional and structural genomics, metabolism and enzymology of organisms
that grow near 100C.
Learn more about this group by contacting Dr. Y. George Zheng (yzheng@uga.edu) or visiting the Chemical Biology website.
Chemical Biology is an interdisciplinary field of study that bridges the traditional fields of chemistry and biology, applying chemical methods to problems in biology. Often, the tools used are compounds produced through synthetic chemistry that are designed with guidance from structural biology to manipulate physiological processes, providing insight as to how these processes work and sometimes leading to the creation of new function.
Functional and structural genomics, metabolism and enzymology of organisms
that grow near 100C.
Our goal is to define the impact of protein post-translational modifications on structure and function in the immune system.
Protein expression, development of commercially relevant monoclonal antibodies.
Plant genome biology with a focus on crops and medicinal plants; Synthetic biology; Evolution of natural product biosynthesis
Post-translational modification including protein acylation, fatty acid metabolism,
prostate stem cell, Src family kinases, prostate cancer, small molecular inhibitor.
Organic and medicinal chemistry; carbohydrate chemistry; glycomimetics; drug design and development with emphasis on multi-drug resistant infectious diseases
Cellular and molecular biology of acidocalcisomes; the role of polyphosphate in trypanosomatids.
Bacterial physiology and metabolic integration using biochemical, genetic and metabolomics approaches.
Metabolomics and systems biology of Caenorhabditis elegans using NMR,
mass spec, and computational approaches.
Prokaryotic metabolism and physiology with emphasis on protein acetylation, toxic metabolites,
and complex metabolic pathway analysis, integration.
Inhibition of glycation and LDL oxidation by natural products and nutraceuticals.
Translational research in biomaterials (antifouling, antiplatelet, antibacterial, and antiviral) for tissue engineering and medical device applications
Lipidomic and metabolomic analyses of antimicrobial resistant pathogens using ion mobility and mass spectrometry
G-protein coupled receptors, molecular pharmacology, signal transduction, ovarian cancer, neural stem cells.
The Huet Lab will use metabolomics and CRISPR-based approaches to understand the mitochondrial and organellar biology of a class of protozoan parasites, the apicomplexans.
Evolutionary systems biology; protein kinase signaling in plants, pathogens and microbes. Evolution and classification of glycoenzymes.
Chemical biology, kinase signaling, cancer, signal transduction, drug discovery.
Regulation of the cell cycle; ubiquitin-mediated proteolysis and development.
The discovery and development of new drugs to prevent or treat malaria and diseases
caused by brain-eating amoebae. Elucidating mechanism(s) of resistance
and discovering new drug treatment regimens, combinations, or strategies to overcome resistance.
The mechanisms of metalloproteins involved in radical generation, oxidative stress protection,
as well as heme synthesis, sensing, aquisition and transport.
Understanding intracellular and intercellular heme transport.
X-ray crystallography of macromolecules, prokaryotic transcriptional regulators.
Biochemistry, molecular, and structural biology of mammalian glycoprotein biosynthesis and catabolism.
Metabolism and drug development against protozoan parasites.
Calcium signaling and storage in Toxoplasma gondii.
Solving biological/biomedical problems with mass spectrometry.
Enzymes involved in amino acid, especially tryptophan, metabolism which may be drug
targets for cancer, hypertension and neurodegenerative diseases.
Development of biorothogonal protein modification techniques, novel caging groups, and photoactivatable antitumor antibiotics.
Application of Nuclear Magnetic Resonance Spectroscopy to the characterization of biologically important systems.
Development of high-throughput structural biology tools, biophysical methods,
NMR, and computer-aided drug-design to investigate drug-protein
interactions and human disease.
X-ray structural biology, the mitochondrial inner membrane space transport system,
structure based vaccine and therapeutic design, improved/automated methods for
synchrotron SAD data collection and structure determination.
Molecular cell biology and biochemistry of proteases associated with isoprenylated protein
maturation and amyloidogenic peptide degradation; cancer; Alzheimer’s disease.
Protein design and engineering, design of anti-virals and immunogens,
protein chemistry and re-purposing of viral surface proteins,
computational biology
Environmental stress biology, using biochemical, biophysical, and ‘omics approaches to define
the roles of toxic metal exposure in chronic and infectious diseases.
Characterizing the assembly of bacterial surface structures, Development of vaccines for viral
and bacterial pathogens, Systems approaches to understanding microbial diseases
Growth-defense tradeoff, phenylpropanoid metabolism and carbon allocation,
gene family evolution and functional diversification, alternative splicing and gene duplication.
Structural biology of transcription regulation, steroid hormone activation and breast cancer.
Structure-function studies by X-ray diffraction, transcription proteins,
structural genomics, phasing methods.
Regulation of host defense and tolerance by Stat transcription factors.
Investigating the regulatory mechanisms of glycosylation using genomic, chemical, and genetic approaches with particular focus on the discovery of novel drugs and targets to treat human diseases.
Role of protein glycosylation in intellectual disability, congenital muscular dystrophy, cancer, and viral infection.
Oxygen- and glycosylation-dependent regulation of polyubiquitin ligases in Dictyostelium and Toxoplasma gondii;
Glycobiology of protozoa.
X-ray crystallographic and biochemical studies of nucleotide sugar metabolism.
Immunological carbohydrate-protein interactions studied by computational simulation and experimental methods.
Nanoparticle-based imaging and drug delivery; radiation therapy and photodynamic therapy
Transport, micronutrient, hypoxia, cancer.
Drug Development, Chemical Biology, Cancer Disease Mechanism, Epigenetics and Genetics, Histone Modifications, Molecular Biology, Biochemistry, Enzymology, and Biophysics.