Drug Discovery & Development Faculty

Learn more about this group by contacting Dr. Eugene Douglass () or visiting the Center for Drug Discovery website.

Drug discovery and development involves identifying new drug targets, synthesis of new chemical or biological entities, preclinical evaluations, and formulation development to maximize therapeutic potential. Members of this multidisciplinary group cover the full spectrum of the drug discovery and development process including areas such as pharmacology, medicinal chemistry, pharmacokinetics (absorption, distribution, metabolism, and excretion), biopharmaceutics (drug transporters), drug analysis, toxicology, and novel drug formulations and delivery (e.g. liposomes, nanoparticles, and gene delivery).

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163AvciFikri

Fikri Avci

Associate Professor
Biochemistry & Molecular Biology

Mechanisms of immune activation by carbohydrate antigens; design and development
of knowledge-based vaccines and therapeutics against pathogens and cancers.
Website

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Michael Bartlett

Georgia Athletic Association Professor
Pharmaceutical & Biomedical Sciences; Neuroscience

ADME of drugs and environmental toxicants; impact of compounds on memory,
cognition, and neuropathic pain; oligonucleotide therapeutics and biomarkers.

Website

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Houjian Cai

Assistant Professor
Pharmaceutical & Biomedical Sciences

Post-translational modification including protein acylation, fatty acid metabolism,
prostate stem cell, Src family kinases, prostate cancer, small molecular inhibitor.

Website

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David Crich

Professor; Georgia Research Alliance Eminent Scholar in Drug Design
Pharmaceutical and Biomedical Sciences; Chemistry

Organic and medicinal chemistry; carbohydrate chemistry; glycomimetics; drug design and development with emphasis on multi-drug resistant infectious diseases

Website

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Brian Cummings

Associate Professor
Neuroscience; Pharmaceutical & Biomedical Sciences; Toxicology

Molecular toxicology, cell signaling, prostate cancer, anti-cancer, kidney.

Website

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Steve Dalton

Professor
GRA Eminent Scholar Chair in Molecular Cell Biology
Biochemistry & Molecular Biology; Neuroscience

Stem cell biology, development of cell therapies for type 1 diabetes and cardiovascular disease. Pluripotent stem cells in early development and induced pluripotent stem cells- cell reprogramming.

Website

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Roberto Docampo

Professor
Cellular Biology

Cellular and molecular biology of acidocalcisomes; the role of polyphosphate in trypanosomatids.

Website

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Eugene Douglass

Assistant Professor
Pharmaceutical & Biomedical Sciences

Multi-drug resistance(MDR) causes most cancer deaths(Nat. Rev. Cancer 2018, 18, 452). We use organic chemistry, cell biology and data-science to overcome MDR.

Website

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Kosuke Funato

Assistant Professor
Biochemistry & Molecular Biology

Molecular and cellular mechanisms of brain tumors; oncohistone mutations; human ES cell-based tumor modeling; tumor heterogeneity and evolution

Website

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Phillip Greenspan

Associate Professor
Pharmaceutical and Biomedical Sciences

Inhibition of glycation and LDL oxidation by natural products and nutraceuticals.

Website

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Neil J. Grimsey

Assistant Professor
Pharmaceutical and Biomedical Sciences

Defining the spatiotemporal regulation of kinase pathways and the regulation of GPCR induced
inflammation and proangiogenic signaling, for the development of therapeutic agents.

Website

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Hitesh Handa

Associate Professor
Pharmaceutical & Biomedical Sciences

Translational research in biomaterials (antifouling, antiplatelet, antibacterial, and antiviral) for tissue engineering and medical device applications

Website

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Donald Harn

Professor
GRA Distinguished Investigator
Infectious Diseases

Mechanistic analysis of parasite induced immune suppression. Translational research
on immuno-modulation pertaining to inflammation based diseases.
Vaccine development and trials.

Website

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Gerald W. Hart

Professor
Biochemistry & Molecular Biology; Eminent Scholar in Drug Discovery;
Complex Carbohydrate Research Center

Nutrient Regulation of Signaling and Transcription: Mechanisms Underlying Diabetes, Neurodegeneration and Cancer

Website

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Eileen Kennedy

Associate Professor
Pharmaceutical & Biomedical Sciences

Chemical biology, kinase signaling, cancer, signal transduction, drug discovery.

Website

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Dennis Kyle

Professor
GRA Eminent Scholar Chair in Antiparasitic Drug Discovery
Cellular Biology & Infectious Diseases

The discovery and development of new drugs to prevent or treat malaria and diseases
caused by brain-eating amoebae. Elucidating mechanism(s) of resistance
and discovering new drug treatment regimens, combinations, or strategies to overcome resistance.

Website

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Dexi Liu

Panoz Professor of Pharmacy
Pharmaceutical & Biomedical Sciences; Neuroscience

Gene therapy, obesity, drug delivery, gene drug discovery.

Website

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Cory Momany

Associate Professor
Pharmaceutical & Biomedical Sciences

X-ray crystallography of macromolecules, prokaryotic transcriptional regulators.

Website

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Silvia Moreno

Professor
Cellular Biology

Metabolism and drug development against protozoan parasites.
Calcium signaling and storage in Toxoplasma gondii.

Website

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Mandi Murph

Associate Professor
Pharmaceutical & Biomedical Sciences

Chemical inhibitors of cancer, chemoresistance, tumor biology and animal models.

Website

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Scott Pegan

Professor
Pharmaceutical & Biomedical Sciences

Antibiotic & antiviral drug discovery, assay development, enzymology,
and structural biology, regulation of innate immune responses.

Website

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S. Mark Tompkins

Professor
Infectious Diseases; Toxicology

Transmission and pathogenicity of zoonotic influenza virus infection and development
of vaccination and the prevention and treatment of viral infections.

Website

Professor Stephen Trent

M. Stephen Trent

UGA Foundation Distinguished Professor
Infectious Diseases

Characterizing the assembly of bacterial surface structures, Development of vaccines for viral
and bacterial pathogens, Systems approaches to understanding microbial diseases

Website

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Ryan Weiss

Assistant Professor
Biochemistry & Molecular Biology, Complex Carbohydrate Research Center

Investigating the regulatory mechanisms of glycosylation using genomic, chemical, and genetic approaches with particular focus on the discovery of novel drugs and targets to treat human diseases.

Website

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Catherine White

Associate Professor
Pharmaceutical & Biomedical Sciences; Toxicology

The influence of gender on the disposition of drugs and drug carriers,
and their subsequent therapeutic or toxic outcomes, and the physiological-based
pharmacokinetic modeling for utilization in predicting toxicity and exposures.

Website

Xie Jin

Jin Xie

Associate Professor
Chemistry

Nanoparticle-based imaging and drug delivery; radiation therapy and photodynamic therapy

Website

Xie, Zhong-Ru

Zhong-Ru (Paul) Xie

Assistant Professor
Bioinformatics

Computational drug discovery, simulation model, new computational tools for drug design

Website

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May Xiong

Associate Professor
Pharmaceutical & Biomedical Sciences

Biomaterial-based systems in the area of iron chelation therapy, biological metal sensors,
overcoming antibiotic drug resistance in Gram-negative bacteria,
and chelation of transfusional iron overload.

Website

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Yao Yao

Assistant Professor
Pharmaceutical and Biomedical Sciences; Neuroscience

Blood Brain Barrier, Stroke, Neurological disorders, Stem Cell Biology, Extracellular Matrix Biology

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Hang Yin

Assistant professor
Biochemistry & Molecular Biology

Stem cell biology, brown fat development and induction, non-coding
RNA, development of novel therapies for human obesity and type 2 diabetes

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Jason Zastre

Associate Professor
Pharmaceutical & Biomedical Sciences; Toxicology

Transport, micronutrient, hypoxia, cancer.

Website

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Nadja Zeltner

Assistant Professor
Biochemistry & Molecular Biology; Cellular Biology; Neuroscience

Effects of pathological stress on cells of the peripheral nervous system and the adrenal gland. In vitro disease modeling using human pluripotent stem cells.

Website

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Y. George Zheng

Professor
Georgia Cancer Coalition Distinguished Scholar
Pharmaceutical & Biomedical Sciences

Drug Development, Chemical Biology, Cancer Disease Mechanism, Epigenetics and Genetics, Histone Modifications, Molecular Biology, Biochemistry, Enzymology, and Biophysics.

Website