Liu, Yang
Yang Liu
Assistant Professor
Institute of Bioinformatics
Microfluidic system development and application for single-cell analysis.
Developing novel therapeutic strategies for colon and breast cancer, both in vitro and in vivo; Identifying and characterizing novel molecules in the tumor microenvironment that influence cancer progression; Studying exosomal miRNAs and their role in cancer metastasis.
The research in Dr. Li’s laboratory combines biochemistry, genetics, adductomics and computational approaches to investigate effects of epigenetics and spatial genome organization on environmental carcinogen-induced DNA damage formation, DNA repair, mutagenesis, and carcinogenesis.
Targeted therapy and cancer chemoprevention; preclinical animal models; cancer immunotherapy; tumor microenvironment and exosomal microRNAs; biomarker of tumor metastasis.
Multi-drug resistance(MDR) causes most cancer deaths(Nat. Rev. Cancer 2018, 18, 452). We use organic chemistry, cell biology and data-science to overcome MDR.
Molecular and cellular mechanisms of brain tumors; oncohistone mutations; human ES cell-based tumor modeling; tumor heterogeneity and evolution
Epigenetic regulation in the context of development and cancer. We focus on heterochromatin and primarily use zebrafish as a model system.
Micro- and nano-technology, lab-on-a-chip systems, microfluidics,
single cell study, cancer diagnostics.
Investigating the regulatory mechanisms of glycosylation using genomic, chemical, and genetic approaches with particular focus on the discovery of novel drugs and targets to treat human diseases.