University of Georgia
The research in Dr. Li’s laboratory combines biochemistry, genetics, adductomics and computational approaches to investigate effects of epigenetics and spatial genome organization on environmental carcinogen-induced DNA damage formation, DNA repair, mutagenesis, and carcinogenesis.
Targeted therapy and cancer chemoprevention; preclinical animal models; cancer immunotherapy; tumor microenvironment and exosomal microRNAs; biomarker of tumor metastasis.
Multi-drug resistance(MDR) causes most cancer deaths(Nat. Rev. Cancer 2018, 18, 452). We use organic chemistry, cell biology and data-science to overcome MDR.
Molecular and cellular mechanisms of brain tumors; oncohistone mutations; human ES cell-based tumor modeling; tumor heterogeneity and evolution
Nutrient Regulation of Signaling and Transcription: Mechanisms Underlying Diabetes, Neurodegeneration and Cancer
Epigenetic regulation in the context of development and cancer. We focus on heterochromatin and primarily use zebrafish as a model system.
Micro- and nano-technology, lab-on-a-chip systems, microfluidics,
single cell study, cancer diagnostics.
Investigating the regulatory mechanisms of glycosylation using genomic, chemical, and genetic approaches with particular focus on the discovery of novel drugs and targets to treat human diseases.
Role of glycosylation in regulating Notch signaling, assisting protein folding, and development.
