University of Georgia
Our goal is to define the impact of protein post-translational modifications on structure and function in the immune system.
The discovery and development of new drugs to prevent or treat malaria and diseases
caused by brain-eating amoebae. Elucidating mechanism(s) of resistance
and discovering new drug treatment regimens, combinations, or strategies to overcome resistance.
Characterizing the assembly of bacterial surface structures, Development of vaccines for viral
and bacterial pathogens, Systems approaches to understanding microbial diseases
Investigating the regulatory mechanisms of glycosylation using genomic, chemical, and genetic approaches with particular focus on the discovery of novel drugs and targets to treat human diseases.
Inhibition of glycation and LDL oxidation by natural products and nutraceuticals.
Prokaryotic metabolism and physiology with emphasis on protein acetylation, toxic metabolites,
and complex metabolic pathway analysis, integration.
Metabolomics and systems biology of Caenorhabditis elegans using NMR,
mass spec, and computational approaches.
Oxygen- and glycosylation-dependent regulation of polyubiquitin ligases in Dictyostelium and Toxoplasma gondii;
Glycobiology of protozoa.
Development of biorothogonal protein modification techniques, novel caging groups, and photoactivatable antitumor antibiotics.
Enzymes involved in amino acid, especially tryptophan, metabolism which may be drug
targets for cancer, hypertension and neurodegenerative diseases.
