University of Georgia
Multi-drug resistance(MDR) causes most cancer deaths(Nat. Rev. Cancer 2018, 18, 452). We use organic chemistry, cell biology and data-science to overcome MDR.
Computational drug discovery, simulation model, new computational tools for drug design
Development of synthetic organic methodologies to produce active pharmaceutical ingredients. Microwave-promoted synthesis of bioactive amines.
Metabolomic approaches applied to drug target selection and validation in human pathogens; discovery and development of new chemotherapeutic interventions.
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Computational biology, functional genomics, kinetics of biochemical reaction networks.
Enzymes involved in amino acid, especially tryptophan, metabolism which may be drug targets for cancer, hypertension and neurodegenerative diseases.
Cancer genomics; human junk DNA; genomic instability.
Drug Development, Chemical Biology, Cancer Disease Mechanism, Epigenetics and Genetics, Histone Modifications, Molecular Biology, Biochemistry, Enzymology, and Biophysics.
Immunological carbohydrate-protein interactions studied by computational simulation and experimental methods.
X-ray structural biology, the mitochondrial inner membrane space transport system, structure based vaccine and therapeutic design, improved/automated methods for synchrotron SAD data collection and structure determination.
