Xie, Jin

Jin Xie
Professor
Chemistry
Nanoparticle-based imaging and drug delivery; radiation therapy and photodynamic therapy
Computational drug discovery, simulation model, new computational tools for drug design
Defining the spatiotemporal regulation of kinase pathways and the regulation of GPCR induced inflammation and proangiogenic signaling, for the development of therapeutic agents.
Effects of pathological stress on cells of the peripheral nervous system and the adrenal gland. In vitro disease modeling using human pluripotent stem cells.
Metabolomic approaches applied to drug target selection and validation in human pathogens; discovery and development of new chemotherapeutic interventions.
Website
The discovery and development of new drugs to prevent or treat malaria and diseases caused by brain-eating amoebae. Elucidating mechanism(s) of resistance and discovering new drug treatment regimens, combinations, or strategies to overcome resistance.
Biomaterial-based systems in the area of iron chelation therapy, biological metal sensors, overcoming antibiotic drug resistance in Gram-negative bacteria, and chelation of transfusional iron overload.
The influence of gender on the disposition of drugs and drug carriers, and their subsequent therapeutic or toxic outcomes, and the physiological-based pharmacokinetic modeling for utilization in predicting toxicity and exposures.
Characterizing the assembly of bacterial surface structures, development of vaccines for viral and bacterial pathogens, systems approaches to understanding microbial diseases
Investigating the regulatory mechanisms of glycosylation using genomic, chemical, and genetic approaches with particular focus on the discovery of novel drugs and targets to treat human diseases.