Clark, Leigh Anne
Leigh Anne Clark
Associate Professor, Department of Genetics
Canine genetics and genomics.
Website
Canine genetics and genomics.
Website
Our lab seeks to uncover novel regulatory mechanisms of biofilm formation to undermine bacterial survival in chronic infections.
Meiotic chromosome biology using Drosophila as a model system.
Bacterial adhesion and biofilm formation, dynamics of bacterial nanomachines, microbial subcellular organization.
Plant genome biology with a focus on crops and medicinal plants; Synthetic biology; Evolution of natural product biosynthesis
Cell differentiation during plant reproduction, genomics and gene regulatory networks, single-cell RNA-sequencing, reprogramming cell fate
We use the advanced genetic mouse models to study the molecular and cellular mechanisms underlying
several diseases: obesity, diabetics, muscle and heart diseases.
Nutritional Genomics; Human Genetics; Population and Quantitative Genomics;
Gene-Diet Interaction during human evolution and in metabolic diseases;
We use the easy genetic system of a soil bacterium, Acinetobacter baylyi ADP1,to study diverse
aspects of gene expression and chromosomal rearrangements.This research has implications
for medical issues (gene amplification), environmental issues (bioremediation),
biotechnology/bioenergy (conversion of lignin to biofuels), and evolution (new methods for experimental evolution).
The regulation of fruit shape and size of tomato and other Solanaceous crops