University of Georgia
Investigating the regulatory mechanisms of glycosylation using genomic, chemical, and genetic approaches with particular focus on the discovery of novel drugs and targets to treat human diseases.
Role of glycosylation in regulating Notch signaling, assisting protein folding, and development.
Metabolomics and systems biology of Caenorhabditis elegans using NMR,
mass spec, and computational approaches.
Oxygen- and glycosylation-dependent regulation of polyubiquitin ligases in Dictyostelium and Toxoplasma gondii; Glycobiology of protozoa.
Arenavirus glycoprotein structure and function; virus entry and membrane fusion; emerging virus-host interactions. Functional characterization of viral glycoproteins and host interactions.
Structural analysis and characterization of glycosaminoglycans using mass spectrometry
Immunological carbohydrate-protein interactions studied by computational simulation and experimental methods.
Role of protein glycosylation in intellectual disability, congenital muscular dystrophy, cancer, and viral infection.
Mechanisms that regulate the expression, function, and structure of tissue-specific glycans.
Biochemistry, molecular, and structural biology of mammalian glycoprotein biosynthesis and catabolism.
