University of Georgia
Targeted therapy and cancer chemoprevention; preclinical animal models; cancer immunotherapy; tumor microenvironment and exosomal microRNAs; biomarker of tumor metastasis.
High throughput genetics to better understand evolution of fungal pathogens and drive antifungal drug discovery.
Translational research in biomaterials (antifouling, antiplatelet, antibacterial, and antiviral) for tissue engineering and medical device applications
Multi-drug resistance(MDR) causes most cancer deaths(Nat. Rev. Cancer 2018, 18, 452). We use organic chemistry, cell biology and data-science to overcome MDR.
Organic and medicinal chemistry; carbohydrate chemistry; glycomimetics; drug design and development with emphasis on multi-drug resistant infectious diseases
The Huet Lab will use metabolomics and CRISPR-based approaches to understand the mitochondrial and organellar biology of a class of protozoan parasites, the apicomplexans.
Defining the spatiotemporal regulation of kinase pathways and the regulation of GPCR induced
inflammation and proangiogenic signaling, for the development of therapeutic agents.
Biomaterial-based systems in the area of iron chelation therapy, biological metal sensors,
overcoming antibiotic drug resistance in Gram-negative bacteria,
and chelation of transfusional iron overload.
The influence of gender on the disposition of drugs and drug carriers,
and their subsequent therapeutic or toxic outcomes, and the physiological-based
pharmacokinetic modeling for utilization in predicting toxicity and exposures.
Inhibition of glycation and LDL oxidation by natural products and nutraceuticals.
