Ramirez, Ana S.
Ana S. Ramirez
Assistant Professor
Biochemistry & Molecular Biology
Structural and mechanistic investigation of the GPI-anchor biosynthesis pathway
Structural and mechanistic investigation of the GPI-anchor biosynthesis pathway
Our research aims to elucidate the mechanism of membrane transporters, flippases, and polymerases involved in bacterial cell wall biosynthesis, unravel how their function influences bacterial adaptation, discover inhibitory molecules for the development of new antimicrobials, and repurpose the activity of these proteins for applications in the synthesis of glycoconjugates. Our lab uses a multidisciplinary approach, combing techniques such as single-particle cryo-electron microscopy (cryo-EM), x-ray crystallography, live cell assays, and various buichemical/biophysical methods to study the function and molecular mechanism of membrane proteins.
Catalytic mechanisms and structure-function correlations of metalloenzymes; biomedically essential oxygenases
Our goal is to define the impact of protein post-translational modifications on structure and function in the immune system.
Structure and function of enzymes involved in plant polysaccharide biosynthesis and modification with the long term goal to develop pathway engineering or targeted genomics approaches for enhanced production of bio-materials, -products, and -fuels.
Computational drug discovery, simulation model, new computational tools for drug design
Metabolomics and systems biology of Caenorhabditis elegans using NMR,
mass spec, and computational approaches.
Oxygen- and glycosylation-dependent regulation of polyubiquitin ligases in Dictyostelium and Toxoplasma gondii; Glycobiology of protozoa.
Enzymes involved in amino acid, especially tryptophan, metabolism which may be drug targets for cancer, hypertension and neurodegenerative diseases.
Immunological carbohydrate-protein interactions studied by computational simulation and experimental methods.