Mechanistic analysis of parasite induced immune suppression. Translational research
on immuno-modulation pertaining to inflammation based diseases.
Vaccine development and trials.
Interactions between microbial pathogens and host immunity in the
mouse model using bacteria that naturally infect mice and
closely related strains that are important human pathogens.
The discovery and development of new drugs to prevent or treat malaria and leishmaniasis.
Elucidating mechanism(s) of resistance and discovering new drug treatment regimens,
combinations, or strategies to overcome resistance.
Human and animal model-based studies of host immune mechanisms in malaria during pregnancy
and immunopathogenic mechanisms that lead to compromise of pregnancy.
Establishment of the parasite/host niche by filarial worms, specifically Brugia malayi, one of the causative agents of lymphatic filariasis.
Human antibody-mediated immunity to inform next-generation
vaccine development; focus on immunity to major viral, bacterial,
and fungal human pathogens using multidisciplinary approaches in
immunology, structural biology,and biochemistry to study
antibody-antigen interactions at the molecular level.
We use ecological and evolutionary theory to study mosquito-parasite interactions,
ecological drivers of transmission, and how environmental change affects transmission.
Vaccine dev for prevention of PCP and COPD, RSV infection, COPD; Immune Activation
and Aging, PAH; Immune-mediated mechanisms of pathogenesis, Type 2 diabetes and
metabolic syndrome, therapeutic testing; chronic immune activation/inflammation.
Transient evolution of pathogens. Evolutionary processes involved in cross-species transmission. Evolutionary constraints in viral epidemiology.
Role of reactive oxygen species in host-microbe interactions of the respiratory mucosa,
neutrophil biology, pathomechanism of Pseudomonas infection in cystic fibrosis.
Bacterial modulation of eukaryotic membrane dynamics for intracellular survival;
SNARE-dependent membrane fusion biochemistry.
Transmission and pathogenicity of zoonotic influenza virus infection and development
of vaccination and the prevention and treatment of viral infections.
Characterizing the assembly of bacterial surface structures, Development of vaccines for viral
and bacterial pathogens, Systems approaches to understanding microbial diseases
Disease intervention strategies for important human pathogens and emerging infectious diseases of zoonotic origin;
mechanisms of immunity; virus-host interface.
Molecular helminthology: in particular the interactions of
anthelmintic drugs with ion channels in the nervous systems
of parasitic helminths, and the molecular basis of drug resistance.