Karls, Russell

Interactions between microbial pathogens and host immunity in the mouse model using bacteria that naturally infect mice and closely related strains that are important human pathogens.
The discovery and development of new drugs to prevent or treat malaria and diseases caused by brain-eating amoebae. Elucidating mechanism(s) of resistance and discovering new drug treatment regimens, combinations, or strategies to overcome resistance.
Disease intervention strategies for important human pathogens and emerging infectious diseases of zoonotic origin; mechanisms of immunity; virus-host interface.
Characterizing the assembly of bacterial surface structures, development of vaccines for viral and bacterial pathogens, systems approaches to understanding microbial diseases
The ecology and evolution of infectious diseases, including measles, pertussis, avian influenza, dengue and polio using computational modeling.
Arenavirus glycoprotein structure and function; virus entry and membrane fusion; emerging virus-host interactions. Functional characterization of viral glycoproteins and host interactions.
Veterinary diagnostics; emerging clinical problems; antibiotic resistance;
epidemiology of diseases with special emphasis in zoonoses.
Role of reactive oxygen species in host-microbe interactions of the respiratory mucosa, neutrophil biology, pathomechanism of Pseudomonas infection in cystic fibrosis.
Characterization of adhesion proteins which mediate host-parasite interactions in Plasmodium falciparum.